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However, animal models cannot fully replicate human disease states, leading to the inability to translate most animal experimental results into human clinical practice(Perel et al

TAO is a complex autoimmune disease that affects structures in the orbit, such as extraocular muscles, orbital fat, and the lacrimal gland

For this purpose, English-language publications (e.g., review articles, meta-analyses, preclinical studies, clinical trials, observational studies), mainly from the last seven years, are analyzed and discussed in this paper